For 2021, The Breast Cancer Research Foundation of Alabama (BCRFA) invested a total of $1,225,000 in Alabama-based breast cancer research with grants funding 20 research projects, including the O'Neal Comprehensive Cancer Center at UAB, Auburn University, CerFlux, the Mitchell Cancer Institute at the University of South Alabama, the University of Alabama, Southern Research, and HudsonAlpha Institute for Biotechnology. The 2021 grant awards increase the BCRFA's lifetime investment total to over $12 million since 1996.

BCRFA dollars often function as seed funding for developing studies, allowing researchers to generate data needed to attract major national funding. Many BCRFA-funded projects have later received national grants from the National Institute of Health and others.